UROTENSIN II (HUMAN)

中文名称:

UROTENSIN II (HUMAN)

中文同义词:

英文名称:

UROTENSIN II (HUMAN)

英文同义词:

UROTENSIN II (HUMAN) HYDROCHLORIDE;UROTENSIN II (HUMAN);ETPDCFWKYCV, HCL (DISULFIDE BRIDGE: 5-10);GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL;GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL HYDROCHLORIDE;Urotensin II human, ≥97% (HPLC);H-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH, HCL (DISULFIDE BRIDGE: 5-10);H-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH

CAS号:

251293-28-4

分子式:

C64H85N13O18S2

分子量:

1388.57

EINECS号:

相关类别:

生化试剂;多肽;其他生化试剂;Peptide;Urotensin receptor

Mol文件:

251293-28-4.mol

储存条件 

-15°C

生物活性

Urotensin II (114-124), human 是一个含 11 个氨基酸的残基肽，是孤儿受体 GPR14 激动剂，是一有效血管收缩剂。

靶点

GPR14

体外研究

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC 50 =0:62±0.17 nM, n=6).

体内研究

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.