NETAMIFTIDE

中文名称:

NETAMIFTIDE

中文同义词:

NEMIFITIDE DITFA

英文名称:

NETAMIFTIDE

英文同义词:

Bis(trifluoroacetate);Netamiftide ditriflutate;NETAMIFTIDE;(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide;Nemifitide diTFA;INN 00835 diTFA

CAS号:

204992-09-6

分子式:

C37H45F7N10O10

分子量:

0

EINECS号:

相关类别:

多肽

Mol文件:

204992-09-6.mol

生物活性

Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。

体外研究

Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.

体内研究

Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses. Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g Dosage: 0.3 mg/kg Administration: IP; daily; for 14 days Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.

Animal Model:

Male Flinders Sensitive Line (FSL) rat weighing 280-320 g

Dosage:

0.3 mg/kg

Administration:

IP; daily; for 14 days

Result:

Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.