黄芪皂苷VI

中文名称:

黄芪皂苷VI

中文同义词:

黄芪皂苷VI;黄芪皂苷VI 黄芪皂苷X2

英文名称:

Astragaloside VI

英文同义词:

Astragaloside VI;(3beta,6alpha,16beta,20R,24S)-20,24-Epoxy-3-[(2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside;β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-3-[(2-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl

CAS号:

84687-45-6

分子式:

C47H78O19

分子量:

947.11

EINECS号:

相关类别:

标准品;saponins

Mol文件:

84687-45-6.mol

生物活性

Astragaloside VI 可通过激活表皮生长因子受体/细胞外信号调节激酶 (EGFR/ERK) 信号通路来加速伤口愈合。

靶点

EGFR

EGFR

体外研究

Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades.

体内研究

Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats.