异土木香内酯
中文名称:
异土木香内酯
中文同义词:
异土木香内酯(异阿兰内酯);异土木香内酯, 来源于土木香;ISOALANTOLACTONE 异土木香内酯 标准品;异土木香内酯;异阿兰内酯;异土木香内酯(标准品);异木香内脂;ISOALANTOLACTONE 异土木香内酯
英文名称:
Isoalantolactone
英文同义词:
11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone;ISOALANTOACTONE;ISOALANTOLACTONE;ISOHELENIN;(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one
CAS号:
470-17-7
分子式:
C15H20O2
分子量:
232.32
EINECS号:
相关类别:
分析对照品;标准品-对照品;分析试剂标准品;中药对照品;标准品;植物提取物;对照品;Miscellaneous Natural Products;chiral;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;植提标准品;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;标准品-中药标准品;标准品 -中药标准品;倍半萜;标准品，对照品;standardized herbal extract
Mol文件:
470-17-7.mol
熔点
115℃
沸点
364.9±42.0 °C(Predicted)
密度
1.07±0.1 g/cm3(Predicted)
储存条件
Sealed in dry,2-8°C
CAS 数据库
470-17-7(CAS DataBase Reference)
NIST化学物质信息
Naphtho(2,3-b)furan-2(3h)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3ar-(3a«alpha»,4a«alpha»,8a«beta»,9a«alpha»))-(470-17-7)
生物活性
Isoalantolactone 是一种烷化剂，用作细胞凋亡 (apoptosis) 诱导剂。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Isoalantolactone exhibits good cytotoxic activity against the K562 human leukaemia cell line (IC 50 =1.2 μM) . The cytotoxic effect of Isoalantolactone on pancreatic carcinoma is evaluated using PANC-1, BxPC3 and HPAC cell lines. Treatment with Isoalantolactone for 24 h inhibits PANC-1 cell growth in a dose-dependent manner. The inhibition rate is above 90% at 80 µM and the concentration to achieve 50% growth inhibition (IC 50 ) is 40 µM. A similar trend in loss of cell viability is observed in BxPC3 and HPAC cells on Isoalantolactone treatment with IC 50 values 43 and 48 µM respectively. Pretreatment with 3 mM N-Acetyl Cysteine (NAC), a specific ROS scavenger, restores the viability of cells indicating that Isoalantolactone exerts cytotoxic effect on cell viability through ROS generation.
体内研究
The acute and chronic toxic effects of Isoalantolactone in CD1 mice are assessed by measuring the changes in body weight, blood biochemistry and histopathology of liver and kidneys in comparison with control groups. Isoalantolactone is well tolerated by mice and no mortality or any sign of pharmacotoxicity are found at a dose of 100 mg/kg during both experimental periods (7 30 days). Body weight gains and food consumption are comparable for control and treated mice during both experimental periods and there were no drug-related changes in histopathological and blood biochemistry parameters. The histopathological changes in liver and kidneys are assessed using hematoxylin and eosin staining and correlated with liver and renal function biomarkers. No obvious morphological changes are observed in liver and kidney structures of control and treatment groups. There is a slight increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level of treatment group at dose day 7 but this increase is not significantly different (P<0.05) from control group. A significant increase in total bilirubin (TBIL) concentration is found in treatment group (1.43±0.26 vs 0.76±0.12 in control, P<0.05) at dose day 7. Similarly the changes in renal function biomarkers are not significantly different (P<0.05) in the serum of control and treatment groups at dose day 7. The concentration of creatinine (Cr) slightly increases whereas concentration of blood urea nitrogen (BUN) slightly decreases in treatment group. The serum level of AST, ALT, TBIL and BUN slightly decreases when mice are injected with Isoalantolactone at a dose of 100 mg/kg for 30 days.
化学性质
白色粒状结晶，溶于乙醇、乙醚、苯和氯仿，微溶于石油醚不溶于水，来源于藏木香,土木香，大叶土木香 Inula grandis，加拿大苍耳 Xanthium canadense，木香 Saussurea lappa [Svn．Aucklandia lappa]，土木香 lnula helenium，喜马旋覆花 Inula royleana，总状土木香 lnula racemosa。
用途
异土木香内酯具有驱虫、抗菌的作用。
危险品标志
Xn
危险类别码
40
安全说明
22-36
海关编码
29322090
