中文名称:
5-(4,5-二甲氧基-2-甲基苄基)-2,4-二氨嘧啶
中文同义词:
5-(4,5-二甲氧基-2-甲基苄基)-2,4-二氨嘧啶;邻里氧普林;二甲氧甲基苯氨嘧啶;二甲氧甲基苯氨嘧啶溶液, 100PPM;奥美普林/甲藜嘧胺;二甲氧甲基苯氨嘧啶(甲黎嘧啶);奥美普林;奥美普林标准品
英文名称:
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
英文同义词:
ORMETHOPRIM;ORMETOPRIM;ORMETOPRIN;OMP;5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine;L-Ascorbic Phosphate Magnesium;2,4-DiaMino-5-92-Methyl-4,5- diMethoxybenzyl)pyriMidine;DiaMino-5-(6-Methylveratryl)pyriMidine
相关类别:
抗生素;兽药;其他兽药标准品;信号转导通路激酶抑制剂;医药原料;原料药;原料药;Active Pharmaceutical Ingredients;Heterocycles;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals
沸点
521.5±60.0 °C(Predicted)
密度
1.223±0.06 g/cm3(Predicted)
储存条件
Keep in dark place,Inert atmosphere,Room temperature
酸度系数(pKa)
7.11±0.10(Predicted)
最大波长(λmax)
287nm(CHCl3)(lit.)
CAS 数据库
6981-18-6(CAS DataBase Reference)
EPA化学物质信息
Ormetoprim (6981-18-6)
生物活性
Ormetoprim 是一种兽用抗菌剂，通常用于水产养殖和家禽行业。Ormetoprim 可用来预防疾病在淡水水产养殖中的传播，也促进家畜的生长。
体内研究
Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and C max (1.2±0.2 μg/mL).
Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), C max (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration.
Animal Model: Hybrid striped bass (565-805 g)
Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)
Administration: I.p. and p.o. administration
Result: I.p.: t 1/2(elim) =7.5 h; t 1/2(abs) =5.4 h; C max =1.2 μg/mL.
P.o.: t 1/2(elim) =3.9 h; t 1/2(abs) =3.9 h; C max =1.6 μg/mL; F=78.5%.
Animal Model:
Hybrid striped bass (565-805 g)
Dosage:
50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)
Administration:
I.p. and p.o. administration
Result:
I.p.: t 1/2(elim) =7.5 h; t 1/2(abs) =5.4 h; C max =1.2 μg/mL.
P.o.: t 1/2(elim) =3.9 h; t 1/2(abs) =3.9 h; C max =1.6 μg/mL; F=78.5%.
