中文名称:

头孢罗林酯

中文同义词:

头孢洛林酯杂质;头孢罗林酯;头孢洛林酯乙酸盐;头孢洛林酯杂质对照品;CEFTAROLINE FOSAMIL醋酸盐

英文名称:

TAK 599

英文同义词:

TAK 599;Ceftaroline fosaMil;PPI 0903;TAK-599 (ceftaroline fosamil);C22H22N8O8PS4. C2H3O2;Ceftaroline Fosamil Acetate;TAK-599; CEFTAROLINE FOSAMIL;TAK599; TAK 599;PPI-0903;PPI0903;PPI 0903;Ceftaroline fosamil acetate salt

CAS号:

400827-46-5

分子式:

C24H25N8O10PS4

分子量:

744.72

EINECS号:

相关类别:

医药原料

Mol文件:

400827-46-5.mol

CAS 数据库

400827-46-5

生物活性

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素，对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。

体内研究

Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% f T>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log 10 kill. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log 10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log 10 CFU.