升麻苷
中文名称:
升麻苷
中文同义词:
升麻素苷, 来源于升麻;PRIM-O-升麻素苷;升麻素苷(升麻苷、升麻素葡萄糖苷);PRIM-O-GLUCOSYLCIMIFUGIN 升麻素苷;升麻素苷(分析标准品);升麻素苷;升麻苷;升麻苷/升麻素葡萄糖苷
英文名称:
CIMIFUGIN BETA-D-GLUCOPYRANOSIDE
英文同义词:
CIMIFUGIN BETA-D-GLUCOPYRANOSIDE;5H-Furo[3,2-g][1]benzopyran-5-one,7-[(β-D-;glucopyranosyloxy)methyl]-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-,(2S)-;Prim-O-glucosylcimifugin, 98%, from Cimicifuga foetida L.;prim-O-Glucosylcimifugin;(2S)-2-(2-hydroxypropan-2-yl)-4-methoxy-7-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,3-dihydrofuro[3,2-g]chromen-5-one;Cimifugin 7-glucoside;rim-O-glucosylcimifugin
CAS号:
80681-45-4
分子式:
C22H28O11
分子量:
468.45
EINECS号:
相关类别:
中药标准品;对照品;植提标准品;中药对照品;标准品;分析标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;分析对照品;标准品-中药标准品;标准品，对照品;标准品 -中药标准品;其它酚类;分析试剂-标准品
Mol文件:
80681-45-4.mol
熔点
118～120℃
沸点
736.9±60.0 °C(Predicted)
密度
1.53±0.1 g/cm3(Predicted)
酸度系数(pKa)
12.94±0.70(Predicted)
CAS 数据库
80681-45-4
概述
升麻苷是伞形科植物防风（Saposhnikovia divaricate (Turcz.) Schischk）未抽花茎植物的干燥根，其主要产地为黑龙江、内蒙、吉林、湖南、贵州、山东等地。
生物活性
Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) 是防风(Radix Saposhnikovia)中的主要成分，长期以来一直应用于传统中医药中治疗发热、风湿和癌症，它表现出潜在的抗癌活性。在LPS激活的 RAW 264.7 巨噬细胞，Prim-O-glucosylcimifugin 可以浓度依赖性的方式下调 NO synthase (iNOS) 和 cyclooxygenase 2 (COX-2) 的mRNA和蛋白质表达。
靶点
COX-2
iNOS
COX-2
iNOS
体外研究
Prim-O-glucosylcimifugin (POG) is the highest content chromone and one of the major active constituents in Radix Saposhnikoviae (RS). Prim-O-glucosylcimifugin exerts anti-inflammatory effects in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 expression by inhibiting JAK2/STAT3 signaling. The cytotoxicity of Prim-O-glucosylcimifugin is measured to LPS-activated Raw 264.7 macrophages. Raw 264.7 macrophages are treated with LPS (1 μg/mL) and increasing concentrations of Prim-O-glucosylcimifugin (15, 50, and 100 μg/mL) for 24 h and cell viability is evaluated by CCK-8 assay. Cell viability is not significantly affected after 24 h and exposure to 15-100 μg/mL Prim-O-glucosylcimifugin as compared with DMSO-treated cells (control). To investigate the anti-inflammatory effect of Prim-O-glucosylcimifugin, whether Prim-O-glucosylcimifugin can affect NO synthesis is examined in LPS-activated RAW 264.7 cells. Macrophages are treated with LPS (1 μg/mL) and various concentrations of Prim-O-glucosylcimifugin (15, 50, and 100 μg/mL) for 24 h. No concentrations are measured in the culture supernatants by Griess reaction. The concentrations of NO in the culture supernatants are markedly increased in response to LPS exposure, and Prim-O-glucosylcimifugin significantly inhibits LPS-induced NO production in a concentration-dependent manner.
体内研究
Bronchoalveolar lavage fluid (BALF) is collected at 7 h after lipopolysaccharide (LPS) administration and the cytokine levels in BALF are measured by ELISA. The levels of TNF-α, IL-1β and IL-6 in BALF are increased dramatically compared with control group. However, pretreatment with Prime-O-glucosylcimifugin (2.5, 5 or 10 mg/kg) significantly down-regulates the levels of TNF-α, IL-1β and IL-6 in a dose-dependent manner (P<0.05, P<0.01).
化学性质
白色结晶粉末，溶于甲醇，来源于防己，防风，华山前胡。
用途
升麻素苷具有抗炎，免疫抑制的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:具有解热、镇痛、抗炎、抗血小板聚集等多种功效。
安全说明
24/25
海关编码
29389090
