中文名称:

5-去氧-6-姜辣醇

中文同义词:

5-去氧-6-姜辣醇;姜酮酚;姜酮酚5-去氧-6-姜辣醇;姜酮酚5-去氧-6-姜辣醇生产厂家;姜酮酚生产厂家;食品级姜酮酚;5-去氧-6-姜辣醇姜酮酚生产厂家;食品级姜酮酚生产厂家

英文名称:

1-(4-hydroxy-3-methoxyphenyl)decan-5-one

英文同义词:

1-(4-hydroxy-3-methoxyphenyl)decan-5-one;3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-;6-paradol;PARADOL;1-(3-Methoxy-4-hydroxyphenyl)-3-decanone;1-(4-Hydroxy-3-methoxyphenyl)decan-3-one;1-(4-Hydroxy-3-methoxyphenyl)-3-decanone;5-Paradol

CAS号:

27113-22-0

分子式:

C17H26O3

分子量:

278.39

EINECS号:

248-228-1

相关类别:

对照品;医药原料;中药对照品;化合物;细胞周期;营养剂;原料;其它酚类;产品2;陕西林奈主打产品

Mol文件:

27113-22-0.mol

沸点 

406.4±30.0 °C(Predicted)

密度 

1.0690 g/cm3

FEMA 

4665 | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE

折射率 

1.5232 (589.3 nm 20℃)

储存条件 

Sealed in dry,Room Temperature

酸度系数(pKa)

10.02±0.20(Predicted)

JECFA Number

2021

用途

5-去氧-6-姜辣醇是有机合成中间体和医药中间体，主要用于实验室研发过程和化工医药合成过程中。

生物活性

Paradol 是一种姜科植物中发现的刺激性酚类物质。在小鼠皮肤癌变中，Paradol结合到环氧合酶 (COX-2) 活性位点，有效抑制肿瘤发展。

靶点

COX-2

COX-2

体外研究

Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.

体内研究

Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.