中文名称:

929895-45-4

中文同义词:

解旋酶FANCJ和DING抑制剂

英文名称:

Phen-DC3 Trifluoromethanesulfonate

英文同义词:

Phen-DC3 Trifluoromethanesulfonate;Phen-DC3 Triflate

CAS号:

929895-45-4

分子式:

C36H26F6N6O8S2

分子量:

848.7474592

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

929895-45-4.mol

熔点 

>260 °C(Solv: ethyl ether (60-29-7))

生物活性

Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。

靶点

IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)

体外研究

In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells.