中文名称:

TYRPHOSTIN RG 14620

中文同义词:

酪氨酸磷酸化抑制剂RG14620;EGFR抑制剂(RG14620);TYRPHOSTIN RG 14620 酪氨酸磷酸化抑制剂RG14620;酪氨酸磷酸化抑制剂RG14620;化合物RG 14620

英文名称:

TYRPHOSTIN RG 14620

英文同义词:

RG-14620;TYRPHOSTIN RG 14620;2-(3,5-DICHLOROPHENYL)-1-(3-PYRIDINYL)ACRYLONITRILE;2-(3-Pyridinyl)-3-(3,5-dichlorophenyl)propenenitrile;RG 14620,, 136831-49-7;3-Pyridineacetonitrile,a-[(3,5-dichlorophenyl)methylene]-;RG 14620; RG-14620; TYRPHOSTIN RG14620;RG14620, >98%

CAS号:

136831-49-7

分子式:

C14H8Cl2N2

分子量:

275.13

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

136831-49-7.mol

熔点 

150-151℃

沸点 

418.2±45.0 °C(Predicted)

密度 

1.355±0.06 g/cm3(Predicted)

储存条件 

−20°C

溶解度 

DMSO: soluble

酸度系数(pKa)

2.97±0.12(Predicted)

敏感性 

Light Sensitive

生物活性

RG14620 (Tyrphostin RG14620)是一种EGFR抑制剂，可直接抑制ABCG2/BCRP的传送功能。

靶点

Target Value EGFR () ABCG2 ()

Target

Value

EGFR ()

ABCG2 ()

体外研究

RG14620 inhibits colony formation (IC 50 =3 μM) and DNA synthesis (IC 50 =1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC 50 =4 μM) and DNA synthesis (IC 50 =1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.

体内研究

RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.

安全说明 

22-24/25

WGK Germany 

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