中文同义词:
细胞增殖抑制剂(F16);4-[(E)-2-(1H-吲哚-3-基)乙烯基]-1-甲基吡啶鎓碘化物
英文同义词:
F16;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE;4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;F-16;COMPOUND F16;Compound F16);F16 (F-16;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;F16 (Neu-overexpressing?Cells?Inhibitor) (Fandachem)
生物活性
F16 是 neu 过表达细胞的有效生长抑制剂，还可以选择性抑制乳腺上皮以及多种小鼠乳腺肿瘤和人乳腺癌细胞系的增殖。F16 是线粒体毒性化合物，根据靶癌细胞的遗传背景触发凋亡或坏死。
体外研究
F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines.
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells.
Cell Proliferation Assay
Cell Line: MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Concentration: 3 μM
Incubation Time: 3 days/7 days
Result: Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected.
Cell Line:
MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Incubation Time:
3 days/7 days
Result:
Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras -transgenic mice was not affected.
