中文名称:

833481-73-5

中文同义词:

BUB1KINASE抑制剂(2OH-BNPP1)

英文名称:

2OH-BNPP1

英文同义词:

2OH-BNPP1;2-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl)phenol;Phenol, 2-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-

CAS号:

833481-73-5

分子式:

C16H19N5O

分子量:

297.36

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

833481-73-5.mol

生物活性

2OH-BNPP1 是一种 BUB1 kinase 抑制剂，可用于癌症研究。

靶点

BUB1 kinase

体外研究

2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.

体内研究

2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.