中文名称:

1218816-71-7

中文同义词:

鞘氨醇激酶1(SPHK1)抑制剂(SK1-IN-1)

英文名称:

(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide

英文同义词:

(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide;SK1-IN-1;SK1 inhibitor 1;2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)-

CAS号:

1218816-71-7

分子式:

C22H30N4O3

分子量:

398.5

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1218816-71-7.mol

生物活性

SK1-IN-1是一种有效的鞘氨醇激酶1 (SPHK1) 抑制剂，IC50 值为58 nM。

靶点

IC50: 58 nM (SPHK1)

体内研究

SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.