中文名称:

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉

中文同义词:

7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉;双位点SRC酪氨酸激酶抑制剂(SRC INHIBITOR 1);6,7-二甲氧基-N-(4-苯氧基苯基)-4-喹唑啉胺;SRC抑制剂1;化合物SRC INHIBITOR 1

英文名称:

6,7-Dimethoxy-N-(4-phenoxyphenyl)-

英文同义词:

6,7-Dimethoxy-N-(4-phenoxyphenyl)-;Src I1;SKI-1;Src Inhibitor-1;Src-l1;ANTI-HHAT (N-TERM) antibody produced in rabbit;HHAT;MART2

CAS号:

179248-59-0

分子式:

C22H19N3O3

分子量:

373.4

EINECS号:

相关类别:

细胞生物学试剂;合成;Amines;Aromatics;Heterocycles;Inhibitors

Mol文件:

179248-59-0.mol

储存条件 

2-8°C

溶解度 

DMSO: >10mg/mL

形态

white powder

生物活性

Src Inhibitor 1是Src和Lck的竞争性抑制剂，IC50分别为44 nM和88 nM。它也能抑制Csk和Yes。

靶点

Target Value Src (Cell-free assay) 44 nM Lck (Cell-free assay) 88 nM

Target

Value

Src (Cell-free assay)

44 nM

Lck (Cell-free assay)

88 nM

体外研究

Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC 50 values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC 50 =0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC 50 =0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency.

危险品标志 

Xn

危险类别码 

22-36/37/38

安全说明 

26

危险品运输编号 

UN 3077 9 / PGIII

WGK Germany 

3