中文名称:

(3S,5S)-阿伐他汀钠盐

中文同义词:

阿伐他汀钠盐;阿托伐他汀USP相关物质E;阿托伐他汀EP杂质E;阿托伐他汀钙杂质E(单体);3S,5S)-阿托伐他汀;(3S,5S)-阿伐他汀钠盐

英文名称:

(3S,5S)-Atorvastatin sodium salt

英文同义词:

(bS,dS)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid;(βS,δS)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid SodiuM;Atorvastatin USP Related CoMpound E;(3S,5S)-Atorvastatin Sodium Salt;S,S-Atorvastatin;1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βS,δS)-;(S,dS)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Sodium;3S,5S-Atorvastatin Sodium

CAS号:

501121-34-2

分子式:

C33H35FN2O5

分子量:

558.64

EINECS号:

相关类别:

对照品-杂质对照品;杂质对照品;Aromatics;Chiral Reagents;Pfizer compounds;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

501121-34-2.mol

熔点 

182-184°C

储存条件 

-20°C Freezer

生物活性

(3S,5S)-Atorvastatin 是 Atorvastatin 的无活性对映异构体。(3S,5S)-Atorvastatin 可以激活孕烷 X 受体 (PXR)。Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。

靶点

Pregnane X receptor (PXR)

体外研究

Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability. (3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC 50 of 12.4 μM. Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence.