中文名称:

羟基氯喹EP杂质D-d5二盐酸

中文同义词:

羟氯喹硫酸EP杂质D DIHBR;脱乙基氯喹DIHBR(硫酸羟氯喹EP杂质D DIHBR);羟基氯喹EP杂质D;羟氯喹杂质9 2HBR;脱乙基氯喹;氯喹相关物质D;去乙基氯喹;去乙基氯喹-D4

英文名称:

DESETHYL CHLOROQUINE

英文同义词:

DESETHYL CHLOROQUINE;Deethylchloroquine;Desethyl Chloroquine DiHBr (Hydroxychloroquine Sulfate EP Impurity D DiHBr);Hydroxychloroquine Sulfate EP Impurity D DiHBr;Chloroquine Impurity 1（Desethyl Chloroquine）;Hydroxychloroquine Sulfate Impurity 4（Hydroxychloroquine Sulfate EP Impurity D）;Hydroxychloroquine Impurity 9 2HBr;Monodeethylchloroquine

CAS号:

1476-52-4

分子式:

C16H22ClN3

分子量:

291.82

EINECS号:

相关类别:

化学试剂;对照品-杂质对照品;Metabolite;Various Metabolites and Impurities;Heterocycles;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals

Mol文件:

1476-52-4.mol

熔点 

94-97?C

沸点 

173-175 °C(Press: 0.05 Torr)

密度 

1.138±0.06 g/cm3(Predicted)

储存条件 

-20°C Freezer

酸度系数(pKa)

10.62±0.19(Predicted)

生物活性

Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。

体外研究

P. falciparum

体内研究

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntingtons disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.

WGK Germany 

3

海关编码 

2933497050