7-胺基去乙酰氧基头胞烷酸

中文名称:

7-胺基去乙酰氧基头胞烷酸

中文同义词:

6-氨基屈;7-胺基去乙酰氧基头胞烷酸;6-AMINOCHRYSENE,10NG/UL 标准品

英文名称:

6-AMINOCHRYSENE

英文同义词:

ADCA;6-Amc;Chrysenex;Chrysonex;6-CHRYSENAMINE;6-AMINOCHRYSENE;AMINOCHRYSENE;AMINOCHRYSENE, 6-

CAS号:

2642-98-0

分子式:

C18H13N

分子量:

243.3

EINECS号:

220-149-7

相关类别:

Mol文件:

2642-98-0.mol

熔点 

209-211 °C(lit.)

沸点 

376.18°C (rough estimate)

密度 

0.8933 (rough estimate)

折射率 

1.4500 (estimate)

储存条件 

2-8°C

酸度系数(pKa)

4.32±0.30(Predicted)

水溶解性 

155ug/L(24 ºC)

Merck 

13,2275

CAS 数据库

2642-98-0(CAS DataBase Reference)

生物活性

6-Aminochrysene (6-Aminochrysene) 是芳香胺类化合物，可用于脾肿大，骨髓性白血病和乳腺癌的研究。

体外研究

6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation.

体内研究

6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration.

危险品标志 

Xn

危险类别码 

22

安全说明 

45-36/37/39-26

WGK Germany 

3

RTECS号

GC0500000

海关编码 

29214900