3-氨基苯甲酰胺

中文名称:

3-氨基苯甲酰胺

中文同义词:

3-氨基苯胺;间氨基苯甲酰胺(三氨基苯甲酰胺);3-氨基苯甲酰胺 5G;3-氨基苯甲酰胺,98%;3-氨基苯丙酰胺98%;3-氯基苯甲酰胺;间氨基苯甲酰胺;3-氨基苯甲酰胺

英文名称:

3-Aminobenzamide

英文同义词:

M-AMINOBENZAMIDE;3-ABA;3-AMINOBENZAMIDE;PARP Inhibitor I, 3-ABA;PARP Inhibitor I, 3-ABA - CAS 3544-24-9 - Calbiochem;3-AMINOBENZAMIDE;INO1001;INO 1001;INO-1001 (3-Aminobenzamide;Aminobenzamide, 3- - AB, 3- | ABA, 3-

CAS号:

3544-24-9

分子式:

C7H8N2O

分子量:

136.15

EINECS号:

222-586-9

相关类别:

有机砌块;小分子抑制剂，天然产物;酰胺;酰胺化合物;细胞生物学试剂;化工原料;A-AM;AMIDE;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides Salts;Amides;Bioactive Small Molecules;Building Blocks;Carbonyl Compounds;Cell Biology;Chemical Synthesis;Organic Building Blocks;Inhibitor;Inhibitors

Mol文件:

3544-24-9.mol

熔点 

115-116 °C (lit.)

沸点 

250.42°C (rough estimate)

密度 

1.1778 (rough estimate)

折射率 

1.5769 (estimate)

储存条件 

room temp

溶解度 

ethanol: 50 mg/mL, clear, faintly yellow

形态

powder

酸度系数(pKa)

16.26±0.50(Predicted)

颜色

white to off-white

水溶解性 

Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).

敏感性 

Light Sensitive

BRN 

2802373

CAS 数据库

3544-24-9(CAS DataBase Reference)

NIST化学物质信息

3-NH2-C6H4CONH2(3544-24-9)

生物活性

3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) 是一种有效的Poly(ADP-ribose)polymerase (PARP)抑制剂，还可通过caspase非依赖性的方式来抑制SCI脊髓损伤后的细胞凋亡。

靶点

Target Value PARP ()

Target

Value

PARP ()

体外研究

3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H 2 O 2 .

体内研究

In a db/db (Lepr db/db ) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD + depletion and improves water maze performance after controlled cortical impact (CCI) in mice.

化学性质 

白色粉末，熔点115-117℃。

用途 

有机化工原料中间体。

类别

有毒物品

毒性分级

中毒

急性毒性

口服-野鸟LD50:  1000 毫克/公斤

可燃性危险特性

可燃;燃烧产生有毒氮氧化物烟雾

储运特性

库房通风低温干燥

灭火剂

干粉、泡沫、砂土、二氧化碳, 雾状水

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36-37/39

危险品运输编号 

3077

WGK Germany 

3

RTECS号

CU8992000

海关编码 

29242990

毒害物质数据

3544-24-9(Hazardous Substances Data)