隐陡头菌素M

中文名称:

隐陡头菌素M

中文同义词:

隐陡头菌素M

英文名称:

illudin M

英文同义词:

illudin M;(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1-cyclopropan]-7(6H)-one;(3S,6R)-2,3-Dihydro-3,6-dihydroxy-2,2,4,6-tetramethylspiro[cyclopropane-1,5-[5H]inden]-7(6H)-one;Spiro[cyclopropane-1,5-[5H]inden]-7(6H)-one, 2,3-dihydro-3,6-dihydroxy-2,2,4,6-tetramethyl-, (3S,6R)-

CAS号:

1146-04-9

分子式:

C15H20O3

分子量:

248.32

EINECS号:

相关类别:

ADC

Mol文件:

1146-04-9.mol

熔点 

120-122.5° (Matsumoto); mp 128-130° (McMorris)

沸点 

452.4±45.0 °C(Predicted)

密度 

1.24±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.57±0.70(Predicted)

生物活性

Illudin M 是一种细胞毒性真菌倍半萜，可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

体外研究

Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro. Apoptosis Analysis Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) Concentration: 0.01 μM, 1 μM, 10 μM Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).

Cell Line:

Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)

Concentration:

0.01 μM, 1 μM, 10 μM

Incubation Time:

24 hours, 48 hours,72 hours, 96 hours, 120 hours

Result:

Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).