B-赤霉醇

中文名称:

B-赤霉醇

中文同义词:

B-赤霉醇;-ZEARALANOL;Β-玉米赤霉醇;BETA-玉米赤霉醇

英文名称:

BETA-ZEARALANOL

英文同义词:

taleranol;BETA-ZEARALANOL;2,4-DIHYDROXY-6-[6BETA,10-DIHYDROXY-UNDECYL)BENZOIC ACID MICRO-LACTONE;Taleranol (β-Zearalanol);B-zearalanol;BETAZERANOL;(3S,7S)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one;(4S)-4β-Methyl-8β,16,18-trihydroxy-3-oxabicyclo[12.4.0]octadecane-1(14),15,17-triene-2-one

CAS号:

42422-68-4

分子式:

C18H26O5

分子量:

322.4

EINECS号:

636-982-8

相关类别:

微生物代谢物;霉菌毒素类;医药原料;Heterpocycles;Aromatics;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

42422-68-4.mol

熔点 

134-137°C

闪点 

2℃

储存条件 

2-8°C

BRN 

4844761

生物活性

Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。

体外研究

βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC 50 of 25 μM. βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC 50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC 50 values of 19.8 uM, 16.8 uM, respectively. βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol. Cell Viability Assay Cell Line: HepG2 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol. Cell Proliferation Assay Cell Line: BGC cells Concentration: 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM Incubation Time: 24 hours Result: Inhibited cell proliferation in a dose-dependent manner. RT-PCR Cell Line: HepG2 cells Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 72 hours Result: Had the higher cytotoxic effect in comparation with α-Zearalenol.

Cell Line:

HepG2 cells

Concentration:

0-100 μM

Incubation Time:

72 hours

Result:

Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.

Cell Line:

BGC cells

Concentration:

0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM

Incubation Time:

24 hours

Result:

Inhibited cell proliferation in a dose-dependent manner.

Cell Line:

HepG2 cells

Concentration:

1 μM, 5 μM, 10 μM

Incubation Time:

72 hours

Result:

Had the higher cytotoxic effect in comparation with α-Zearalenol.

危险品标志 

T,Xn,F

危险类别码 

60-36/37/38-36-20/21/22-11

安全说明 

53-36/37/39-45-36/37-16

危险品运输编号 

UN 1648 3 / PGII

WGK Germany 

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