盐酸土霉素

中文名称:

盐酸土霉素

中文同义词:

盐酸氧四环素;(4S,4aR,5S,5aR,6S,12aS)-4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-2-并四苯甲酰胺盐酸盐;土霉素盐酸;酸土霉素;盐酸土霉素;盐酸土霉素(标准品);OXYTETRACYCLINE HCL 盐酸土霉素;OXYTERACYCLINE HCL 土霉素盐酸盐

英文名称:

Oxytetracycline hydrochloride

英文同义词:

hydrocyclin;liquamycininjectable;mepatar;nsc9169;5-hydroxytetracycline hydrochloride;[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride;GEOMYCIN;AQUACYCLINE

CAS号:

2058-46-0

分子式:

C22H25ClN2O9

分子量:

496.89

EINECS号:

218-161-2

相关类别:

微生物代谢物;抗菌;四环素类药;抗生素类药物;四环素类;医药中间体;抗生素类;饲料添加剂;农业和环境标准品;兽药抗菌原料;化合物：原料药;生化试剂;化工中间体;化学试剂;对照品;中间体;化工原料;医药兽药;原料中间体-原料药;兽药原料;化工原料-原料药;兽药原料药;农用兽用原料;原料药API;Amines;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals;L - ZEPA;NeatsAntibiotics;TetracyclinesMore...Close...;1694 PharmaceuticalsPersonal Care Products;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;Mechanism of Action;Pharmaceutical intermediate;抗生素;原料药;医药原料;分析标准品;盐酸土霉素;医用原料;原料;药物杂质及中间体;添加剂;中药对照品;化工原料;化工中间体

Mol文件:

2058-46-0.mol

熔点 

180°C

比旋光度 

-188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis)

储存条件 

0-6°C

溶解度 

Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline.

形态

crystalline

颜色

yellow

PH值

2.0～3.0 (10g/l, 25℃)

水溶解性 

>100 g/L

最大波长(λmax)

360nm(H2O)(lit.)

敏感性 

Light Sensitive

Merck 

14,6976

BRN 

3853107

CAS 数据库

2058-46-0(CAS DataBase Reference)

EPA化学物质信息

Oxytetracycline hydrochloride (2058-46-0)

生物活性

Oxytetracycline hydrochloride 是一种属于四环素类的抗生素。Oxytetracycline hydrochloride 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline hydrochloride 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline hydrochloride 还具有抗 HSV-1 的活性。

靶点

HSV-1 Bacterial Human Endogenous Metabolite

HSV-1

Bacterial

体外研究

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

体内研究

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis , the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter. For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

用途 

属广谱抗菌素，其抗菌谱、抗菌原理与四环素基本相同

用途 

主要对于革兰阳性菌和脑膜炎球菌、淋病球菌等革兰阴性菌具有抗菌活性

用途 

靠阻止氨基酰-tRNA结合到30S亚单位上抑制蛋白合成。 抗菌谱: 革兰氏阴性和阳性细菌。 耐药性模式: 活性丧失， 核糖体保护, 四环素失活。

危险品标志 

Xn,Xi

危险类别码 

63

安全说明 

45-53-36/37/39

WGK Germany 

2

RTECS号

QI8225000

F 

8-10-23

TSCA 

Yes

海关编码 

29413000

毒性

LD50 oral in mouse: 6696mg/kg