六羟黄酮/栎草亭

中文名称:

六羟黄酮/栎草亭

中文同义词:

六羟黄酮/栎草亭;栎草亭,槲皮万寿菊素;栎草亭;3,3,4,5,6,7-六羟基黄酮;槲皮万寿菊素栎草亭

英文名称:

3,3,4,5,6,7-HEXAHYDROXYFLAVONE

英文同义词:

QuercetagitrinQuercetagetin 7-glucoside;QUERCETAGIN;QUERCETAGENIN;QUERCETAGETIN;3,3,4,5,6,7-HEXAHYDROXYFLAVONE;3,5,6,7,3,4-HEXAHYDROXYFLAVONE;2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone;2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one

CAS号:

90-18-6

分子式:

C15H10O8

分子量:

318.24

EINECS号:

201-973-6

相关类别:

对照品;植物提取物;标准品;Flavanols

Mol文件:

90-18-6.mol

熔点 

>300°C

沸点 

732.4±60.0 °C(Predicted)

密度 

1.912±0.06 g/cm3(Predicted)

酸度系数(pKa)

6.12±0.40(Predicted)

生物活性

Quercetagetin (6-Hydroxyquercetin) 是从 Citrus unshiu (C. unshiu) 果皮中分离的主要类黄酮。Quercetagetin 是一种中等强度和选择性的，细胞渗透性的 pim-1 激酶抑制，IC50 为 0.34 μM。具有抗炎和抗肿瘤活性。

靶点

PIM1 0.34 μM (IC 50 ) PIM2 3.45 μM (IC 50 ) RSK2 2.82 μM (IC 50 ) PKA 21.2 μM (IC 50 )

PIM1 0.34 μM (IC 50 )

PIM2 3.45 μM (IC 50 )

体外研究

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC 50 s of 3.45, 21.2, and 2.82 µM, respectively. Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM. Cell Viability Assay Cell Line: RWPE2 prostate cancer cells Concentration: 0.1, 1, 10, and 100 μM Incubation Time: 72 hours Result: Inhibited growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM.

Cell Line:

RWPE2 prostate cancer cells

Concentration:

0.1, 1, 10, and 100 μM

Incubation Time:

72 hours

Result:

Inhibited growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM.

体内研究

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively. Animal Model: SKH-1 hairless mice model Dosage: 4 or 20 nmol Administration: Topical application; 28 weeks Result: Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

Animal Model:

SKH-1 hairless mice model

Dosage:

4 or 20 nmol

Administration:

Topical application; 28 weeks

Result:

Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

化学性质 

来源于万寿菊