N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-

中文名称:

N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸

中文同义词:

N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸;芴甲氧羰基-苏氨酸(半乳糖胺(AC)3-Α-D)基;FMOC-THR[GALNAC(AC)3-伪-D]-OH;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸,GALNAC L-THREONINE;半乳糖胺L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸

英文名称:

FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH

英文同义词:

N-FMOC-O-(3,4,6,-TRI-O-ACETYL-2-ACETAMIDO-2-DEOXY-Α-D-GALACTOPYRANOSYL)-L-THREONINE;Fmoc-L-Ser(α-D-GalNAc(Ac)3)-OH;Fmoc-L-Thr(GalNAc(Ac)3-α-D)-OH;Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine≥ 97% (HPLC);Fmoc-Thr(AcAcNH-α-Gal)-OH Novabiochem;GalNAc-Thr;2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-a-D-galactopyranosyl-Fmoc threonine;L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-

CAS号:

116783-35-8

分子式:

C33H38N2O13

分子量:

670.66

EINECS号:

相关类别:

糖基氨基酸;糖基化氨基酸;生化试剂;糖氨基酸和糖肽;基准试剂;Glycoamino Acid;Carbohydrates Derivatives;Amino Acid;Fluorescent Labels Indicators;Inhibitors;Protein Kinase Inhibitors and Activators

Mol文件:

116783-35-8.mol

熔点 

178-183°C

沸点 

857.1±65.0 °C(Predicted)

密度 

1.38±0.1 g/cm3(Predicted)

储存条件 

-20°C

酸度系数(pKa)

3.32±0.10(Predicted)

旋光性 (optical activity)

[α]22/D +55.0°, c = 1% in chloroform

InChIKey

OXLCJWGAUPPZQJ-ZNHCDWFHSA-N

CAS 数据库

116783-35-8

生物活性

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是用于研究制备癌症疫苗的结构单元。

体外研究

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.

WGK Germany 

3

海关编码 

2932 99 00